DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA
Identifieur interne : 000104 ( Main/Exploration ); précédent : 000103; suivant : 000105DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA
Auteurs : Hussein N. Yassine [États-Unis] ; Etienne Croteau ; Varun Rawat [États-Unis] ; Joseph R. Hibbeln [États-Unis] ; Stanley I. Rapoport [États-Unis] ; Stephen C. Cunnane ; John C. Umhau [États-Unis]Source :
- Alzheimer's Research & Therapy [ 1758-9193 ] ; 2017.
Abstract
The apolipoprotein E ɛ4 (
Using positron emission tomography, regional incorporation coefficients (
The mean global gray matter DHA incorporation coefficient,
Our findings suggest an increase in the DHA incorporation coefficient in several brain regions in
Url:
DOI: 10.1186/s13195-017-0250-1
PubMed: 28335828
PubMed Central: 5364667
Affiliations:
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Yassine</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>2250 Alcazar Street, Room 210, Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>2250 Alcazar Street, Room 210, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Croteau, Etienne" sort="Croteau, Etienne" uniqKey="Croteau E" first="Etienne" last="Croteau">Etienne Croteau</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9064 6198</institution-id><institution-id institution-id-type="GRID">grid.86715.3d</institution-id><institution>Research Center on Aging,</institution><institution>University of Sherbrooke,</institution></institution-wrap>Sherbrooke, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Rawat, Varun" sort="Rawat, Varun" uniqKey="Rawat V" first="Varun" last="Rawat">Varun Rawat</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2156 6853</institution-id><institution-id institution-id-type="GRID">grid.42505.36</institution-id><institution>Department of Medicine,</institution><institution>University of Southern California,</institution></institution-wrap>2250 Alcazar Street, Room 210, Los Angeles, CA 90033 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>2250 Alcazar Street, Room 210, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hibbeln, Joseph R" sort="Hibbeln, Joseph R" uniqKey="Hibbeln J" first="Joseph R." last="Hibbeln">Joseph R. Hibbeln</name><affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0481 4802</institution-id><institution-id institution-id-type="GRID">grid.420085.b</institution-id><institution></institution><institution>Section on Nutritional Neurosciences, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health,</institution></institution-wrap>Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Rapoport, Stanley I" sort="Rapoport, Stanley I" uniqKey="Rapoport S" first="Stanley I." last="Rapoport">Stanley I. Rapoport</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2297 5165</institution-id><institution-id institution-id-type="GRID">grid.94365.3d</institution-id><institution></institution><institution>Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health,</institution></institution-wrap>Bethesda, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Cunnane, Stephen C" sort="Cunnane, Stephen C" uniqKey="Cunnane S" first="Stephen C." last="Cunnane">Stephen C. Cunnane</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9064 6198</institution-id><institution-id institution-id-type="GRID">grid.86715.3d</institution-id><institution>Research Center on Aging,</institution><institution>University of Sherbrooke,</institution></institution-wrap>Sherbrooke, QC Canada</nlm:aff><wicri:noCountry code="subfield">QC Canada</wicri:noCountry></affiliation></author><author><name sortKey="Umhau, John C" sort="Umhau, John C" uniqKey="Umhau J" first="John C." last="Umhau">John C. Umhau</name><affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0481 4802</institution-id><institution-id institution-id-type="GRID">grid.420085.b</institution-id><institution></institution><institution>Section on Nutritional Neurosciences, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health,</institution></institution-wrap>Rockville, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Rockville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2243 3366</institution-id><institution-id institution-id-type="GRID">grid.417587.8</institution-id><institution></institution><institution>Division of Psychiatry Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration,</institution></institution-wrap>College Park, MD USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>College Park</wicri:cityArea></affiliation></author></analytic><series><title level="j">Alzheimer's Research & Therapy</title><idno type="eISSN">1758-9193</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The apolipoprotein E ɛ4 (<italic>APOE4</italic>) allele is the strongest genetic risk factor identified for developing Alzheimer’s disease (AD). Among brain lipids, alteration in the ω-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) homeostasis is implicated in AD pathogenesis. <italic>APOE4</italic> may influence both brain DHA metabolism and cognitive outcomes.</p></sec><sec><title>Methods</title><p>Using positron emission tomography, regional incorporation coefficients (<italic>k</italic>*), rates of DHA incorporation from plasma into the brain using [1-<sup>11</sup>C]-DHA (<italic>J</italic><sub>in</sub>), and regional cerebral blood flow using [<sup>15</sup>O]-water were measured in 22 middle-aged healthy adults (mean age 35 years, range 19–65 years). Data were partially volume error-corrected for brain atrophy. APOE4 phenotype was determined by protein expression, and unesterified DHA concentrations were quantified in plasma. An exploratory post hoc analysis of the effect of <italic>APOE4</italic> on DHA brain kinetics was performed.</p></sec><sec><title>Results</title><p>The mean global gray matter DHA incorporation coefficient, <italic>k</italic>*, was significantly higher (16%) among <italic>APOE4</italic> carriers (<italic>n</italic> = 9) than among noncarriers (<italic>n</italic> = 13, <italic>p</italic> = 0.046). Higher DHA incorporation coefficients were observed in several brain regions, particularly in the entorhinal subregion, an area affected early in AD pathogenesis. Cerebral blood flow, unesterified plasma DHA, and whole brain DHA incorporation rate (<italic>J</italic><sub>in</sub>) did not differ significantly between the <italic>APOE</italic> groups.</p></sec><sec><title>Conclusions</title><p>Our findings suggest an increase in the DHA incorporation coefficient in several brain regions in <italic>APOE4</italic> carriers. These findings may contribute to understanding how <italic>APOE4</italic> genotypes affect AD risk.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weisgraber, Kh" uniqKey="Weisgraber K">KH Weisgraber</name></author><author><name sortKey="Innerarity, Tl" uniqKey="Innerarity T">TL Innerarity</name></author><author><name sortKey="Mahley, Rw" uniqKey="Mahley R">RW Mahley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vitali, C" uniqKey="Vitali C">C Vitali</name></author><author><name sortKey="Wellington, Cl" uniqKey="Wellington C">CL Wellington</name></author><author><name sortKey="Calabresi, L" uniqKey="Calabresi L">L Calabresi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boehm Cagan, A" uniqKey="Boehm Cagan A">A Boehm-Cagan</name></author><author><name sortKey="Bar, R" uniqKey="Bar R">R Bar</name></author><author><name sortKey="Liraz, O" 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Fonteh</name></author><author><name sortKey="Schneider, Ls" uniqKey="Schneider L">LS Schneider</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li></region></list><tree><noCountry><name sortKey="Croteau, Etienne" sort="Croteau, Etienne" uniqKey="Croteau E" first="Etienne" last="Croteau">Etienne Croteau</name><name sortKey="Cunnane, Stephen C" sort="Cunnane, Stephen C" uniqKey="Cunnane S" first="Stephen C." last="Cunnane">Stephen C. Cunnane</name></noCountry><country name="États-Unis"><region name="Californie"><name sortKey="Yassine, Hussein N" sort="Yassine, Hussein N" uniqKey="Yassine H" first="Hussein N." last="Yassine">Hussein N. Yassine</name></region><name sortKey="Hibbeln, Joseph R" sort="Hibbeln, Joseph R" uniqKey="Hibbeln J" first="Joseph R." last="Hibbeln">Joseph R. Hibbeln</name><name sortKey="Rapoport, Stanley I" sort="Rapoport, Stanley I" uniqKey="Rapoport S" first="Stanley I." last="Rapoport">Stanley I. Rapoport</name><name sortKey="Rawat, Varun" sort="Rawat, Varun" uniqKey="Rawat V" first="Varun" last="Rawat">Varun Rawat</name><name sortKey="Umhau, John C" sort="Umhau, John C" uniqKey="Umhau J" first="John C." last="Umhau">John C. Umhau</name><name sortKey="Umhau, John C" sort="Umhau, John C" uniqKey="Umhau J" first="John C." last="Umhau">John C. Umhau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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